DAOkids®: Pediatric dietary management of DAO deficiency / histamine intolerance.

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DAOkids

DAOkids® contains DAO enzyme, and is suitable for pediatric use in the dietary management of Attention Deficit Hyperactivity Disorder (ADHD) caused by DAO Deficiency.

Pediatric dietary management of DAO deficiency / histamine intolerance.

  Highly active and bioavailable Diamine Oxidase (DAO) enzyme. Ideal for prolonged dietary management of DAO Deficiency.

  Gastroresistant tablets that allow the Diamine Oxidase enzyme not to be released in the stomach, but in a delayed form in the small intestine, where it carries out its effects.

  DAO intake through DAOfood helps to increase the breakdown of exogenous or dietary histamine in the gut.

  Based on scientific and clinical evidence in Medical Nutrition.

Product description

DAOkids® is a is a food for special medical purposes for the dietary management of ADHD caused by DAO Deficiency.

DAOkids® supports digestive health by breaking down histamine and supporting normal DAO levels.

The Diamine Oxidase (DAO) contained in DAOkids® serves as a supplement to the enzyme found in the body, which is in charge of metabolizing histamine. Taking one tablet of DAOkids® before each meal increases the amount of DAO in the small bowel and therefore also boosts histamine degradation. This accelerates in the digestive tract the processing of the histamine found in different foods, that triggers the symptoms.

The amount of DAO contained in DAOkids® complements the body’s own enzyme, enhancing the breakdown of dietary histamine. Thus, DAOkids® supports histamine metabolism locally in the small intestine and restores the natural balance of histamine and DAO.

Histamine is an essential molecule, a transmitter that belongs to the so-called group of biogenic amines and that is naturally present in many foods as well as inside our cells. Normally, the intake of histamine contained in food does not cause any problem, since it is quickly processed and metabolized by the Diamine Oxidase enzyme (DAO).

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DAO is the main enzyme for the metabolism of ingested histamine. lt is mainly located in the intestinal epithelium, where it absorbs and degrades the ingested histamine preventing it from passing into the bloodstream.

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When there is an imbalance between the ingested histamine and the enzyme capacity or activity to metabolize it, histamine passes into the bloodstream which can trigger different reactions. Some causes of lower DAO Deficiency include genetic and acquired origin.

Histamine is present in all foods a greater or lesser extent, whether plant or animal origin. Food undergoing a lengthy maturation or food stored for an extended period is particularly high in histamine and other biogenic amines also degraded by DAO enzyme.

These foods are, among others:

  • Raw or pasteurized milk and dairy products.
  • Citrus fruits, strawberries and banana.
  • Seafood, oily fish and fish sauces.
  • Raw cured sausage such as spiced sausage, chorizo or bacon.
  • Some vegetables such as tomatoes, spinach or aubergines.
  • Alcoholic drinks*, especially red and sparkling wine.

*Alcoholic drinks contain, to some extent, histamine or other biogenic amines, and furthermore, alcohol inhibits DAO activity impeding histamine degradation and metabolization.

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What does DAOkids® contain?

DAOkids® contains gastro-resistant tablets with controlled release DAO in the intestine that prevent stomach acid pH and tablets that guarantee the immediate release of adjuvant active ingredients.

  60 white/beige gastroresistant tablets with intestinal release of DAO.

How should DAOKids® be used?

Take 1 tablet with some water 20 minutes before the main meals (3 times a day). DAOkids® tablets have a gastro-resistant coating that allows the enzyme Diamine Oxidase not to be released in the stomach, but in a delayed manner in the small bowel, which is where the histamine ingested in the diet is degraded. Therefore, the tablets should not be chewed or split, but swallowed whole.

lmportant observations

Store in a cool place. The tablets must be swallowed whole. It does not contain Histamine. Gluten free. Lactose free.

Storage

DAOkids® contains Diamine Oxidase (DAO), a thermolabile enzyme (sensitive to temperature) that should be stored away from heat sources. No special preservation precautions are required if daily intake guidelines are followed. In the case of occasional use, the product should be kept refrigerated.

Ingredients: Bulking agents: microcrystalline cellulose and hydroxypropyl cellulose; pig kidney protein extract with 7% diamine oxidase (DAO); glazing agent: ethyl cellulose; potato starch; stabilizers: sodium alginate and magnesium salts of fatty acids; medium chain triglycerides; glazing agent: hydroxypropyl methylcellulose; stabilizers: oleic acid and stearic acid.

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Histamine

Histamine is a molecule that is present in all foods in the daily diet, is also produced endogenously in the body, and is the mediator of many biological processes such as hypersensitivity of the body’s defense reactions, gastric acid secretions, neuromodulation and regulation of immune function. Ingested histamine is broken down by the enzyme Diamine Oxidase (DAO) in the small intestine.

The issue

If the metabolic activity of the DAO enzyme is reduced, the ingested histamine cannot be degraded and passes through the intestinal mucosa to the bloodstream.

The solution

DAOkids® provides the exogenous DAO intake necessary to restore histamine metabolism. Proper DAO supplementation allows dietary management of DAO levels.

FAQs

DAOkids® contains DAO enzyme and is suitable for pediatric use in the dietary management of Attention Deficit Hyperactivity Disorder caused by DAO Deficiency.

The enzyme Diamine Oxidase (DAO) from DAOkids® maintains its metabolic activity of food histamine for 4-5 hours after taking the supplement.

The normal recommended dose is one capsule (or tablet) before each meal. Up to 3 capsules or tablets can be taken before meals rich in histamine.

The results of dietary management should begin to be seen within 15 days of
supplementation and within the first 30 days.

DAOkids® can be taken indefinitely, being suitable for diabetics, celiacs and / or people with food intolerance, it does not contain allergens, gluten, lactose or histamine, and it does not cause side effects.

Each dose of DAOkids® contains 4.2 mg of pig kidney protein extract rich in DAO enzyme with an enzymatic activity of 0.41 mU/20,000 HDU per dose. The maximum daily dose is 12.6 mg of pork kidney protein extract rich in DAO enzyme, equivalent to the intake of 3 tablets a day.

RELATED INFO

Histamine in food

Several foods provoke histamine accumulation in the organism, but not all are necessarily rich in this amine. High intakes of foods rich in other amines such as putrescine,

Que es el Déficit de DAO
What is DAO Deficiency?

DAO Deficiency is an alteration in the metabolism of food histamine that occurs when the activity of the Diamine Oxidase (DAO) enzyme is reduced. That is, when for

Histamine in food

Several foods provoke histamine accumulation in the organism, but not all are necessarily rich in this amine. High intakes of foods rich in other amines such as putrescine,

Que es el Déficit de DAO
What is DAO Deficiency?

DAO Deficiency is an alteration in the metabolism of food histamine that occurs when the activity of the Diamine Oxidase (DAO) enzyme is reduced. That is, when for