fibroDAO®: Dietary management of fibromyalgia caused by DAO deficiency / Histamine intolerance.

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FibroDAO® contains DAO enzyme and magnesium and is suitable for the dietary management of fibromyalgia caused by DAO Deficiency.

Dietary management of fibromyalgia caused by DAO deficiency / Histamine intolerance.

    Highly active and bioavailable Diamine Oxidase (DAO) enzyme. Ideal for prolonged dietary management of DAO deficiency.

  It includes magnesium as adjuvant ingredient that work in synergy with the DAO enzyme.

  With the innovative Eficaps® technology based on capsules with gastroresistant tablets that allow the release of the ingredients at the required time and place of action.

  DAO intake through fibroDAO helps to increase the breakdown of exogenous or dietary histamine in the gut.

Product description

fibroDAO® is a food for special medical purposes for the dietary management of fibromyalgia caused by DAO Deficiency.

fibroDAO® supports digestive health by breaking down histamine and supporting normal DAO levels.

The amount of DAO contained in fibroDAO® complements the body’s own enzyme, enhancing the breakdown of dietary histamine. Thus, fibroDAO® supports histamine metabolism locally in the small intestine and, in combination with quercetin and vitamin C as adjuvants, restores the natural balance of histamine and DAO.

Histamine is an essential molecule, a transmitter that belongs to the so-called group of biogenic amines and that is naturally present in many foods as well as inside our cells. Normally, the intake of histamine contained in food does not cause any problem, since it is quickly processed and metabolized by the Diamine Oxidase enzyme (DAO).

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DAO is the main enzyme for the metabolism of ingested histamine. lt is mainly located in the intestinal epithelium, where it absorbs and degrades the ingested histamine preventing it from passing into the bloodstream.

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When there is an imbalance between the ingested histamine and the enzyme capacity or activity to metabolize it, histamine passes into the bloodstream which can trigger different reactions. Some causes of lower DAO Deficiency include genetic and acquired origins.

Histamine is present in all foods a greater or lesser extent, whether plant or animal origin. Food undergoing a lengthy maturation or food stored for an extended period is particularly high in histamine and other biogenic amines also degraded by DAO enzyme.

These foods are, among others:

  • Raw or pasteurized milk and dairy products.
  • Citrus fruits, strawberries and banana.
  • Seafood, oily fish and fish sauces.
  • Raw cured sausage such as spiced sausage, chorizo or bacon.
  • Some vegetables such as tomatoes, spinach or aubergines.
  • Alcoholic drinks*, especially red and sparkling wine.

*Alcoholic drinks contain, to some extent, histamine or other biogenic amines, and furthermore, alcohol inhibits DAO activity impeding histamine degradation and metabolization.

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What does fibroDAO® contain?

Eficaps® capsules of fibroDAO® contain gastro-resistant tablets with controlled release DAO in the intestine that prevent stomach acid pH and tablets that guarantee the immediate release of adjuvant active ingredients.

Each capsule contains four tablets:

  2 DAO white/beige gastro-resistant tablets with release into the intestine.

  2 purple immediate-release tablets containing magnesium..

(*) If you can not take magnesium, you can open the capsule and remove the lilac tablets.

How should fibroDAO® be used?

Take 1 capsule with some water 20 minutes before the main meals (3 times a day). The capsule should be swallowed whole, if you are unable to swallow it whole, please open it and ingest the tablets from its interior separately, swallowing them whole without chewing, splitting or breaking them.

lmportant observations

fibroDAO® does not a single food source. Alcohol and medicines may largely inhibit the action of the Diamine Oxidase enzyme (DAO). To be used only under the supervision of a qualified practitioner, who shall recommend the dosage according to the symptoms. Keep out of the reach of children. Store in a cool place. The capsules must be swallowed whole. It does not contain Histamine. Gluten free. Lactose free.

Storage

fibroDAO® contains Diamine Oxidase (DAO), a thermolabile enzyme (sensitive to temperature) that should be stored away from heat sources. No special preservation precautions are required if daily intake guidelines are followed. In the case of occasional use, the product should be kept refrigerated.

Bulking agents: microcrystalline cellulose and hydroxypropyl cellulose; magnesium oxide (magnesium); potato starch; glazing agents: ethyl cellulose and hydroxypropyl methylcellulose; pig kidney protein extract with 7% diamine oxidase DAO); rice starch; stabilizers: magnesium salts of fatty acids, sodium alginate and stearic acid; medium-chain triglycerides and oleic acid; glazing agent: dicalciumphosphate; apple concentrate, blackcurrant, radish, spirulina and apple. Vegetable capsule: hydroxypropyl methylcellulose.

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Histamine

Histamine is a molecule that is present in all foods in the daily diet, is also produced endogenously in the body, and is the mediator of many biological processes such as inflammation, allergies, gastric acid secretions, neuromodulation and regulation of immune function.

Under normal conditions, ingested histamine is broken down by the enzyme Diamine Oxidase (DAO) in the small intestine.

The problem

If the metabolic activity of the DAO enzyme is reduced (due to genetic, pharmacological and / or pathological factors), the ingested histamine cannot be degraded and passes through the intestinal mucosa to the circulation causing the appearance of gastrointestinal, cutaneous, neurological and muscular symptoms associated to DAO deficiency.

The solution

fibroDAO® provides the exogenous DAO intake necessary to restore histamine metabolism. Proper DAO supplementation allows dietary management of fibromyalgia caused by DAO deficiency / histamine intolerance

FAQs

According to the International Society of DAO Deficiency, some of the associated conditions can be migraine, dry skin, atopy, fibromyalgia, chronic fatigue, ADHD, constipation, diarrhea and bloating.

Not all symptoms described above are necessarily present, but it is known that most individuals with reduced DAO activity manifest, on average, three or four of these symptoms, with migraine being particularly prevalent among them. However, equally, not all symptoms and conditions described above are necessarily linked to DAO Deficiency.

The enzyme Diamine Oxidase (DAO) from fibroDAO® maintains its metabolic activity of food histamine for 4-5 hours after taking the supplement.


The normal recommended dose is one capsule (or tablet) before each meal. Up to 3 capsules or tablets can be taken before meals rich in histamine.

The results of dietary management should begin to be seen within 15 days of
supplementation and within the first 30 days.

fibroDAO® can be taken indefinitely, being suitable for diabetics, celiacs and / or people with food intolerance, it does not contain allergens, gluten, lactose or histamine, and it does not cause side effects.

Each capsule contains 0.3 mg of diamine oxidase enzyme (DAO) in two white/beige tablets (each gastro-resistant tablet contains 0.15 mg of DAO enzyme). The maximum daily dose is 12.6 mg of pork kidney protein extract rich in DAO enzyme, equivalent to the intake of 3 capsules a day (each capsule contains 4.2 mg of pork kidney protein extract rich in DAO enzyme).

RELATED INFO

Histamine in food

Several foods provoke histamine accumulation in the organism, but not all are necessarily rich in this amine. High intakes of foods rich in other amines such as putrescine,

Que es el Déficit de DAO
What is DAO Deficiency?

DAO Deficiency is an alteration in the metabolism of food histamine that occurs when the activity of the Diamine Oxidase (DAO) enzyme is reduced. That is, when for

Histamine in food

Several foods provoke histamine accumulation in the organism, but not all are necessarily rich in this amine. High intakes of foods rich in other amines such as putrescine,

Que es el Déficit de DAO
What is DAO Deficiency?

DAO Deficiency is an alteration in the metabolism of food histamine that occurs when the activity of the Diamine Oxidase (DAO) enzyme is reduced. That is, when for